ArticleNature biotechnology2025
Computational prediction of human genetic variants in the mouse genome.
Article in Nature biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Mouse models of human disease should resemble human genetics. Here we present H2M (human-to-mouse), a computational pipeline to predict mouse genetic variants that mirror the sequence and functional effects of human variants. H2M can also perform mouse-to-human and paralog-to-paralog variant mapping for precision genome-editing tools. We provide a database of >3 million human-mouse mutation pairs, base- and prime-editing libraries for 4,944 variant pairs and a web tool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.