ArticleScientific reports2025
The Hungarian cross-cultural adaptation of the MMQL-AF for measuring quality of life in adolescents with cancer.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With improvements in childhood cancer survival, attention has shifted toward health-related quality of life (HRQoL) and long-term treatment effects. This study aimed to validate the Hungarian version of the Minneapolis-Manchester Quality of Life Instrument - Adolescent Form (MMQL-AF) and explore factors associated with HRQoL among adolescents and young people with cancer. Ninety-two patients with cancer (46 receiving active treatment and 46 ≥ 1 year post-treatment) and 46 healthy controls completed the MMQL-AF. The MMQL-AF was translated into Hungarian in accordance with Beaton et al. and TARES (2024) guidelines. Reliability was assessed using Cronbach's alpha and intra-class correlation coefficients (ICCs). Validity was evaluated by correlations with the Hungarian Pediatric Quality of Life Inventory (PedsQL 4.0) and by comparing scores across groups. Five items were removed during confirmatory factor analysis (CFA) to improve model fit. The MMQL-AF demonstrated acceptable reliability (Cronbach's alpha 0.73-0.90; ICC 0.78-0.96; RMSEA = 0.062; 90% CI: 0.055-0.069; CFI = 0.828; TLI = 0.814; SRMR = 0.079; GFI = 0.962) and strong concurrent validity with PedsQL scores. Cancer patients reported significantly lower HRQoL than healthy peers (mean 3.58 vs. 3.81; mean difference 0.23; 95% CI: 0.05-0.41; p = 0.012). No significant difference emerged between patients on active treatment and patients off treatment. Patients with bone, soft-tissue, or central nervous system tumors reported worse outcomes (p = 0.015). Positive parental relationships were strongly associated with a better outlook (p < 0.001). The Hungarian MMQL-AF demonstrated acceptable reliability and validity for assessing HRQoL among adolescents and young people with cancer. Tumor type and family environment were associated with differences in the well-being of the patients. This instrument enables comprehensive HRQoL assessment in Hungarian pediatric oncology, supporting identification of at-risk groups and informing survivorship care strategies tailored to medical and psychosocial needs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.