Articlenpj aging2025
Cognitive aging clock based on Explainable artificial intelligence.
Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Biological clocks aim to estimate the physiological state of an organism, or of specific organs or systems, from the perspective of aging. The inferred individual age acceleration is presumably linked to increased mortality and morbidity risks. Here, we introduce a cognitive aging clock based on a battery of five tests (sensomotor arithmetic, sensomotor mirror letter, 1-back, campimetry and the Stroop), capturing sensory and verbal perception, working memory, and decision-making in the context of cognitive conflict. The developed LightGBM machine learning model has the cognitive age MAE of 7.6 years. SHAP analysis yields the overall and individualized interpretations of accelerated aging. In particular, we demonstrate the dominant contribution of Stroop and campimetry test variables to cognitive age. The cognitive age is accelerated in the patients with dementia, whereas moderate cognitive impairment also shows the acceleration trend, but lacks statistical significance. MoCA test score is negatively associated with cognitive age deviation.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.