Evidence map›Paper›PMID 41413043›Full record

ArticleNature communications2025

Intervention timing and disease stage shape tecovirimat and cidofovir efficacy in male SCID mice.

Xinyu Cao, Ning Shi, Xiangshu Qiu, Jiaxin Tian, Peng Wang, Bocheng Liu, Zhuo Ha, He Zhang, Chao Shang, Xiao Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xinyu Cao *Key Laboratory of Pathogen Infection Prevention and Control (MOE), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102629, China.ORCID http://orcid.org/0009-0004-8656-7282
Ning Shi *State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Xiangshu QiuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China.
Jiaxin TianChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China.
Peng WangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China.
Bocheng LiuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China.
Zhuo HaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China.
He ZhangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China.
Chao ShangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China.
Xiao LiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China.
Yubiao XieChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China. 877216599@163.com.ORCID http://orcid.org/0009-0000-4771-3356
Yuelong ShuKey Laboratory of Pathogen Infection Prevention and Control (MOE), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102629, China. yshu@ipbcams.ac.cn.ORCID http://orcid.org/0000-0001-9279-0916
Huijun LuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China. huijun_lu@126.com.ORCID http://orcid.org/0000-0003-4532-4466

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, mpox virus (MPXV) continues to pose a global public health challenge, with immunocompromised individuals often exhibiting more severe clinical symptoms. This study screens three male mouse models (ICR, IFNAR1

Indexed as

Antiviral AgentsBenzamidesCidofovirCytosineIsoindolesOrganophosphonatesAnimalsDisease Models, AnimalHumansMaleMiceMice, KnockoutMice, SCIDAntiviral AgentsBenzamidesCidofovirCytosineIsoindolesOrganophosphonates

Identifiers

PMID41413043
PMCPMC12827245

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.