Evidence map›Paper›PMID 41412800›Full record

ArticleGenes & development2026

Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer.

Liliana Garcia-Martinez, Mengsheng Zha, Rodrigo L Borges, Tong Liu, Gretter González-Blanco, Alana Martinez Alonso, Stephanie Stransky, Simone Sidoli, Hao Zhu, Zheng Wang and 1 more

Abstract read
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liliana Garcia-Martinez *Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.
Mengsheng Zha *Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.
Rodrigo L BorgesSylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.
Tong LiuDepartment of Computer Science, University of Miami, Coral Gables, Florida 33124, USA.
Gretter González-BlancoSylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.
Alana Martinez AlonsoSylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.
Stephanie StranskyDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Simone SidoliDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Hao ZhuDepartment of Computer Science, University of Miami, Coral Gables, Florida 33124, USA.
Zheng WangDepartment of Computer Science, University of Miami, Coral Gables, Florida 33124, USA; lmorey@med.miami.edu zwang@cs.miami.edu.
Lluis MoreySylvester Comprehensive Cancer Center, Miami, Florida 33136, USA; lmorey@med.miami.edu zwang@cs.miami.edu.

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2019 to 2026
$24.1M
Advanced algorithms to infer and analyze 3D genome structuresR35GM137974 · NIGMS · UNIVERSITY OF MIAMI CORAL GABLES · PI WANG, ZHENG · 2020 to 2024
$1.8M
Altering the chromostasis and genome stability by modulating histone methylationR01GM146409 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MOREY, LLUIS, VERDUN, RAMIRO ERNESTO · 2022 to 2025
$1.7M
Mechanisms of RING1B and PRC1 complexes in transcriptional activationR01GM141349 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Lluis Morey · 2022 to 2026
$1.6M
Epigenetic dependencies and vulnerabilities in endocrine-resistant breast cancerR01CA288742 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Lluis Morey · 2025 to 2026
$892k
NCI NIH HHS P30 CA240139NCI NIH HHS R01 CA288742NIGMS NIH HHS R01 GM141349NIGMS NIH HHS R01 GM146409NIGMS NIH HHS R35 GM137974
6 · The paper itself

Abstract

Chromatin architecture plays a key role in development and cancer, yet most studies lack mechanistic depth due to widespread epigenomic remodeling. To address this, we tracked chromatin structure dynamics during the progression of endocrine resistance in ER

Indexed as

Breast NeoplasmsChromatinEpigenesis, GeneticCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHistonesHumansJumonji Domain-Containing Histone DemethylasesMethylationChromatinHistonesJumonji Domain-Containing Histone Demethylasesbreast cancerepigeneticsreprogramming

Identifiers

PMID41412800
PMCPMC12849445

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.