ReviewGenes & development2026
Nuclear receptor coregulator interactions: beyond the switch.
Review in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear receptors (NRs) are ligand-regulated transcription factors (TFs) that respond to hormonal, nutritional, and environmental signals. NRs as druggable targets are known for their therapeutic potential in treating a wide range of diseases, including metabolic disorders, inflammatory conditions, and various cancers. Due to their structure and ability to interact with DNA, ligands, and other proteins, NR transcriptional regulatory capacity is fine-tuned through dynamic interactions with a disparate array of coregulators, including coactivators and corepressors that form an intricate network that integrates multiple signaling and metabolic pathways. This review synthesizes insights into the functional interactions between NRs and the modulators of transcription, focusing on interactions between NRs and coregulators and how their model of interaction has evolved from a binary switch to a coregulator shift mechanism in regulating ligand-dependent transcription. These nuanced multifaceted interactions collectively direct dynamic gene expression by NRs across multiple tissues in physiology and diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.