Evidence map›Paper›PMID 41412616›Full record

ArticleBMJ open2025

The feasibility of salivary melatonin in assessing perioperative circadian rhythm in surgical patients: study protocol for a multicentre prospective study in China.

Baixin Chen, Shiqi Yuan, Pihong Wei, Fengyun Jing, Mingke Zhu, Xu Zhang, Yan Zhang, Yuehua Zhang, Huadong Wang, Zifan Su and 8 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Baixin ChenDepartment of Anesthesiology, Peking University Third Hospital, Beijing, China.
Shiqi YuanSchool of Basic Medical Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0009-0007-4768-4322
Pihong WeiDepartment of Anesthesiology, Affiliated Taian City Central Hospital of Qingdao University, Tai'an, Shandong, China.
Fengyun JingDepartment of Anesthesiology, Peking University Third Hospital, Beijing, China.
Mingke ZhuDepartment of Neurosurgery, Peking University Third Hospital, Beijing, Beijing, China.
Xu ZhangDepartment of Neurosurgery, Peking University Third Hospital, Beijing, Beijing, China.
Yan ZhangDepartment of Thoracic Surgery, Affiliated Taian City Central Hospital of Qingdao University, Tai'an, Shandong, China.
Yuehua ZhangDepartment of Anesthesiology, Affiliated Taian City Central Hospital of Qingdao University, Tai'an, Shandong, China.
Huadong WangDepartment of Anesthesiology, Affiliated Taian City Central Hospital of Qingdao University, Tai'an, Shandong, China.
Zifan SuDepartment of Anesthesiology, Affiliated Taian City Central Hospital of Qingdao University, Tai'an, Shandong, China.
Jia YangDepartment of Anesthesiology, Peking University Third Hospital, Beijing, China.
Yehong LuoDepartment of Anesthesiology, Peking University Third Hospital, Beijing, China.
Yiming LiuDepartment of Anesthesiology, Peking University Third Hospital, Beijing, China.
Haokun NingDepartment of Anesthesiology, Peking University Third Hospital, Beijing, China.
Zhengqian LiDepartment of Anesthesiology, Peking University Third Hospital, Beijing, China.ORCID http://orcid.org/0000-0001-6758-0685
Xiangyang GuoDepartment of Neurosurgery, Peking University Third Hospital, Beijing, Beijing, China.ORCID http://orcid.org/0000-0002-6746-3929
Yanan SongDepartment of Anesthesiology, Peking University Third Hospital, Beijing, China songyanan@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-1747-1373
Zaiqi YangDepartment of Anesthesiology, Affiliated Taian City Central Hospital of Qingdao University, Tai'an, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCircadian rhythm disturbance is associated with neurologic, metabolic, cardiovascular and immune disorders. As the most reliable biomarker of endogenous circadian rhythms, melatonin regulates the sleep-wake cycle and promotes sleep. Studies have demonstrated that saliva and plasma melatonin levels show strong correlations in non-surgical populations. However, the relationship between salivary and plasma melatonin measurements in patients undergoing surgery is unknown. This study will analyse the correlation between the peak concentrations of salivary and blood melatonin in perioperative patients. METHODS AND ANALYSIS: In this prospective study, 102 patients scheduled for thoracic or neurosurgical procedures are being enrolled. The primary outcome of this study is to analyse the correlation between the peak concentrations of salivary and plasma melatonin (measured at 04:00 on the first postoperative day) in patients. ETHICS AND DISSEMINATION: The study protocol has been approved by the Medical Ethics Committee of Peking University Third Hospital (M2023009). The results of the study will be published in peer-reviewed international journals. TRIAL REGISTRATION NUMBER: The study has been registered at the Chinese Clinical Trial Registry (www.chictr.org.cn) with identifier ChiCTR2300070470. The latest version of the trial protocol was approved in October 2023.

Indexed as

Circadian RhythmMelatoninSalivaAdultBiomarkersChinaFeasibility StudiesFemaleHumansMaleMulticenter Studies as TopicPerioperative PeriodProspective StudiesBiomarkersMelatoninANAESTHETICSClinical ProtocolsPatient Care ManagementProspective studiesSleep medicineSURGERY

Identifiers

PMID41412616
PMCPMC12716594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.