ReviewThe American journal of pathology2026
Emerging Mechanistic Roles of STING Signaling in Kidney Diseases.
Review in The American journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The Role and Therapeutic Potential of the STING Signaling Pathway in the Pathogenesis of Diabetic Nephropathy.Pharmaceuticals (Basel, Switzerland) · 2026Review
- The Role of Mitochondria in Polycystic Kidney Disease.International journal of molecular sciences · 2026Review
- Case Report: Genetically primed hyperinflammation: cytomegalovirus-triggered HLH-like syndrome in an adolescent with a gain-of-function STING1 (p.Arg281Trp) variant with novel autosomal dominant inheritance and atypical presentation.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Stimulator of interferon genes (STING), an effector protein anchored in the endoplasmic reticulum, translocates to Golgi upon activation. Canonically recognized for its central function in innate immune defense against cytosolic endogenous or exogenous double-stranded DNA from damaged host cells or pathogens, STING is now known to have noncanonical functions beyond innate immune surveillance. These novel noncanonical functions of STING include modulating autophagy, maintaining endoplasmic reticulum and mitochondrial calcium homeostasis, interacting with endoplasmic reticulum stress sensor protein, and regulating Golgi proton efflux and integrity of the secretory pathway. Recent research in murine models has linked aberrant STING activation to kidney disorders, including acute kidney injury, podocytopathies, chronic kidney disease, apolipoprotein L1-mediated kidney disease, autosomal dominant polycystic kidney disease, and autosomal dominant tubulointerstitial kidney disease. This review summarizes the diverse functions of STING in addition to interferon signaling, highlighting its emerging importance in the pathogenesis of kidney disease and underscoring its promise as a drug target.
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Registered trials
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