Evidence map›Paper›PMID 41412048›Full record

ArticleJournal of hazardous materials2026

Impact of nanoplastics emitted from incineration of polyethylene plastic on THP-1 macrophage viability and immune function.

Lila Bazina, Glen M Deloid, Leonardo Calderon, Luke Fritzky, Nachiket Vaze, Irini Tsiodra, Nikolas Mihalopoulos, Theodoros Pyrsopoulos, Philip Demokritou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hazardous materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lila BazinaNanoscience and Advanced Materials Center, Environmental and Occupational Health Sciences Institute (EOHSI), Rutgers Biomedical Health Sciences, Rutgers University, Piscataway, NJ 08854, USA; Department of Environmental Occupational Health and Justice, School of Public Health, Rutgers University, Piscataway, NJ 08854, USA.
Glen M DeloidNanoscience and Advanced Materials Center, Environmental and Occupational Health Sciences Institute (EOHSI), Rutgers Biomedical Health Sciences, Rutgers University, Piscataway, NJ 08854, USA.
Leonardo CalderonNanoscience and Advanced Materials Center, Environmental and Occupational Health Sciences Institute (EOHSI), Rutgers Biomedical Health Sciences, Rutgers University, Piscataway, NJ 08854, USA.
Luke FritzkyNew Jersey Medical School, Cancer Institute of New Jersey, Rutgers University, Newark, NJ 07103, USA.
Nachiket VazeNanoscience and Advanced Materials Center, Environmental and Occupational Health Sciences Institute (EOHSI), Rutgers Biomedical Health Sciences, Rutgers University, Piscataway, NJ 08854, USA.
Irini TsiodraInstitute for Environmental Research and Sustainable Development, National Observatory of Athens, Athens 15236, Greece.
Nikolas MihalopoulosInstitute for Environmental Research and Sustainable Development, National Observatory of Athens, Athens 15236, Greece.
Theodoros PyrsopoulosNanoscience and Advanced Materials Center, Environmental and Occupational Health Sciences Institute (EOHSI), Rutgers Biomedical Health Sciences, Rutgers University, Piscataway, NJ 08854, USA; Department of Biological Sciences, School of Arts and Sciences, Rutgers University, Piscataway, NJ 08854, USA.
Philip DemokritouNanoscience and Advanced Materials Center, Environmental and Occupational Health Sciences Institute (EOHSI), Rutgers Biomedical Health Sciences, Rutgers University, Piscataway, NJ 08854, USA; Department of Environmental Occupational Health and Justice, School of Public Health, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: philip.demokritou@rutgers.edu.

Funding

Intestinal uptake, translocation, biodistribution, and toxicity of ingested environmentally relevant micro-nanoplastics (MNPs) and the role of inflammation using advanced cellular and in vivo modelsR01ES036043 · NIEHS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Philip Demokritou, MICHAEL P. VERZI · 2024 to 2026
$1.9M
NIEHS NIH HHS R01 ES036043
6 · The paper itself

Abstract

Inhalation exposure to micro-nanoplastics (MNPs) generated by plastic waste incineration is an emerging public health concern. This study assessed the impact of nanoparticles emitted during the incineration of high-density polyethylene (HDPE-I) on THP-1 lung macrophages. HDPE-I nanoparticles (<0.1 µm) were generated using an Integrated Exposure Generation System and collected with a Compact Cascade Impactor. Elemental and chemical analysis of HDPE-I revealed large amounts of sulfur, multiple metals (aluminum, magnesium, calcium, potassium, and iron), and high concentrations of toxic high molecular weight polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs), including the highly carcinogenic PAH benzo[c]fluorene. The overall carcinogenicity potential of HDPE-I PAHs, in benzo[a]pyrene equivalents (BaP

Indexed as

Air PollutantsIncinerationMacrophagesMicroplasticsNanoparticlesPolyethyleneCell SurvivalHumansMembrane Potential, MitochondrialPhagocytosisPolycyclic Aromatic HydrocarbonsTHP-1 CellsAir PollutantsMicroplasticsPolycyclic Aromatic HydrocarbonsPolyethyleneMicro-nanoplasticsPhagocytosisPlastic incinerationPlastic pollutionPolycyclic aromatic hydrocarbonsTHP-1 macrophages

Identifiers

PMID41412048
PMCPMC13175122

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.