Evidence map›Paper›PMID 41411863›Full record

ArticlePoultry science2026

Alginate encapsulation enhanced the gastrointestinal stability and bactericidal efficacy of an optimized Salmonella phage cocktail for oral delivery in poultry feed.

Siwaporn Prachoochote, Sujintana Janesomboon, Preeda Phothaworn, Patoo Withatanung, Janet Y Nale, Edouard E Galyov, Martha R J Clokie, Sunee Korbsrisate, Veerachat Muangsombut

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Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siwaporn PrachoochoteDepartment of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Sujintana JanesomboonDepartment of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Preeda PhothawornDepartment of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand; Current address: Department of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand.
Patoo WithatanungDepartment of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Janet Y NaleCentre for Epidemiology and Planetary Health, School of Veterinary Medicine and Biosciences, Scotland's Rural College, Inverness IV2 5NA, United Kingdom.
Edouard E GalyovBecky Mayer Centre for Bacteriophage Research and Division of Microbiology and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester LE1 9HN, United Kingdom.
Martha R J ClokieBecky Mayer Centre for Bacteriophage Research and Division of Microbiology and Infection, School of Biological and Biomedical Sciences, College of Life Sciences, University of Leicester, Leicester LE1 9HN, United Kingdom.
Sunee KorbsrisateDepartment of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Veerachat MuangsombutDepartment of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. Electronic address: veerachat.mua@mahidol.ac.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Salmonella is a leading cause of gastroenteritis, and it is transmitted via contaminated water and food sources, especially poultry products. Many serovars are resistant to frontline antibiotics, necessitating the need for alternative treatment strategies. Bacteriophage (phage) therapy offers a promising alternative to antibiotics for Salmonella infection control in poultry, however, oral delivery is limited by the highly acidic gastric environment. Thus, this study aimed to optimize a cocktail of encapsulated phages to preserve and enhance their shelf-life, viability, target release and activity in the digestive tract of chickens. The phage cocktail, consisting of three strictly lytic Salmonella phages (ST-W23, SE-W112, and ST-W139) isolated from wastewater, exhibited a broad host range, lysing ∼83 % (107/129) of 25 important Salmonella serovars identified from chicken farms. To enhance stability in acidic conditions, the phage cocktail was encapsulated in alginate-CaCO

Indexed as

AlginatesChickensPhage TherapyPoultry DiseasesSalmonellaSalmonella Infections, AnimalSalmonella PhagesAdministration, OralAnimal FeedAnimalsGastrointestinal TractAlginatesAlginate encapsulationGastroenteritisOral deliveryPhage stabilityPhage therapyPoultry feedSalmonella

Identifiers

PMID41411863
PMCPMC12950429

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.