Evidence map›Paper›PMID 41411654›Full record

ArticleGut microbes2025

Impacts of COVID-19 pandemic on early life gut microbiome.

Lin Zhang, Wenye Xu, Henry Y H Meng, Jessica Y L Ching, Yingzhi Liu, Shilan Wang, Shuai Yan, Ling Lin, Pui K Cheong, Ka L Ip and 15 more

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Lin ZhangMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0003-1634-3780
Wenye XuMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.
Henry Y H MengDepartment of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Jessica Y L ChingMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0001-8257-2843
Yingzhi LiuMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.
Shilan WangMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-9334-8924
Shuai YanMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.
Ling LinMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.
Pui K CheongMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.
Ka L IpMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.
Ye PengMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.
Jie ZhuMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.
Chun P CheungMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.
Ting F LeungDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Agnes S Y LeungDepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Wing H TamDepartment of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Tak Y LeungDepartment of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Paul K S ChanDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Eugene B ChangDepartment of Medicine, Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, IL, USA.
David T RubinDepartment of Medicine, Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago, Chicago, IL, USA.
Erika C ClaudDepartment of Pediatrics, Pritzker School of Medicine/Biological Sciences Division, University of Chicago, Chicago, IL, USA.
William K K WuDepartment of Anaesthesia and Intensive Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Hein M TunMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.
Francis K L ChanMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.
Siew C NgMicrobiota I-Center (MagIC), The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-6850-4454

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

Increased hygiene and sanitation are theorized to predispose to developing atopic diseases, a process potentially mediated by the gut microbiome. We hypothesized that the gut microbiome maturation has been altered by COVID-19 lockdown measures during the first year of life, a critical period when environmental exposure shapes human microbiome development. The two large pre- and during-COVID-19 mother-baby pairs cohorts in the Greater Bay Area of China provided the unique opportunity to assess the effect of increased hygiene standards on early gut microbiome maturation. Our results showed that the gut microbiome diversity, composition, and developmental trajectory were significantly altered between pre- and during-COVID-19 cohorts. Functionally, there was decreased richness in both antimicrobial peptide resistance genes and antibiotic resistance genes in the during-COVID cohort. Specially,

Indexed as

COVID-19Gastrointestinal MicrobiomeAnti-Bacterial AgentsBacteriaChinaCohort StudiesDrug Resistance, BacterialFecesFemaleHumansHygieneInfantInfant, NewbornMalePandemicsSARS-CoV-2Anti-Bacterial AgentsCOVID-19early lifeenvironment and public healthgut microbiomehygiene hypothesispandemics

Identifiers

PMID41411654
PMCPMC12931694

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.