Evidence map›Paper›PMID 41411474›Full record

ArticleJACC. Clinical electrophysiology2026

Low-Dose Cardiac Radiation Improves Electrical Function and Reduces Ventricular Arrhythmogenesis in Mice With Nonischemic Cardiomyopathy.

Devaki A Abhyankar, Marissa R Pennino, Lauren N Pedersen, Felicia Grogan, Amanda Klass, Carla Valenzuela Ripoll, Sherwin Ng, Zhen Guo, Hamidreza Hajirezaei, Stacey L Rentschler and 6 more

Abstract read
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In one paragraph

Article in JACC. Clinical electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Devaki A AbhyankarDepartment of Medicine-Cardiology, University of California-Los Angeles, Los Angeles, California, USA; Department of Bioengineering, University of California-Los Angeles, Los Angeles, California, USA.
Marissa R PenninoDepartment of Medicine-Cardiology, University of California-Los Angeles, Los Angeles, California, USA.
Lauren N PedersenDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Felicia GroganDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Amanda KlassDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Carla Valenzuela RipollDepartment of Medicine, Division of Cardiology, Washington University School of Medicine in St Louis, Saint Louis, Missouri, USA.
Sherwin NgDepartment of Medicine, Division of Cardiology, Washington University School of Medicine in St Louis, Saint Louis, Missouri, USA.
Zhen GuoJohn Cochran VA Medical Center, St. Louis, Missouri, USA.
Hamidreza HajirezaeiDepartment of Medicine, Division of Cardiology, Washington University School of Medicine in St Louis, Saint Louis, Missouri, USA.
Stacey L RentschlerDepartment of Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri, USA.
Clifford G RobinsonDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Phillip S CuculichCenter for Noninvasive Cardiac Radiotherapy, Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri, USA.
Joel D SchillingDepartment of Medicine and Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Carmen BergomDepartment of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Ali JavaheriDepartment of Medicine, Division of Cardiology, Washington University School of Medicine in St Louis, Saint Louis, Missouri, USA; John Cochran VA Medical Center, St. Louis, Missouri, USA.
Olujimi A AjijolaDepartment of Medicine-Cardiology, University of California-Los Angeles, Los Angeles, California, USA. Electronic address: OAjijola@mednet.ucla.edu.

Funding

Apolipoprotein M: a novel regulator of myocardial AutophagyR01HL155344 · NHLBI · WASHINGTON UNIVERSITY · PI JAVAHERI, ALI · 2021 to 2025
$3.1M
Understanding Modulation of Neuronal Subpopulations by Sympathetic GliaR01HL162717 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A · 2022 to 2025
$2.4M
Genetic Modifiers of Radiation Therapy-Induced CardiotoxicityR01HL147884 · NHLBI · WASHINGTON UNIVERSITY · PI BERGOM, CARMEN · 2019 to 2023
$2.3M
NHLBI NIH HHS R01 HL147884NHLBI NIH HHS R01 HL155344NHLBI NIH HHS R01 HL162717
6 · The paper itself

Abstract

backgroundClinical cardiac radiation therapy (RT-25 Gy) decreases ventricular tachycardia (VT). Nonischemic cardiomyopathy (NICM) murine studies showed improved left ventricular (LV) ejection fraction (LVEF) with low-dose RT (LDRT-5 Gy), attributed to a decrease in macrophages. However, whether LDRT reduces VT remains unknown.

objectivesThe goal of this study was to investigate the effects of LDRT on VT in NICM mice.

methodsNICM was modeled by using long-chain acyl-CoA synthetase-1 (ACSL1

resultsNICM mice treated with LDRT exhibited higher LVEF and lower VA. LDRT resulted in faster conduction velocity and lower activation time. LDRT mice exhibited greater sympathetic nerve density and reduced innervation heterogeneity. CSF1R mice exhibited greater LVEF. No differences were observed in VA, conduction velocity, or activation time in CSF1R mice vs vehicle-treated mice. CSF1R mice had greater nerve density, although they presented no differences in innervation heterogeneity.

conclusionsIn NICM mice, LDRT improved LV function and reduced spontaneous VA correlated with improved sympathetic nerve distribution, a known risk factor for VT. Decreasing macrophage abundance did not recapitulate the effects of LDRT on VA. Further studies are needed to validate these findings and explore antiarrhythmic mechanisms of LDRT.

Indexed as

Arrhythmias, CardiacCardiomyopathiesTachycardia, VentricularAnimalsDisease Models, AnimalMacrophagesMaleMiceMice, Transgeniccardiac radiation therapycardiac sympathetic innervationheart failureventricular tachycardia

Identifiers

PMID41411474
PMCPMC13191696

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.