Evidence map›Paper›PMID 41411425›Full record

ArticleScience (New York, N.Y.)2025

Trifluoromethylation of alkyl electrophiles with

Chao Wang, Paul DeMent, Susovan Jana, Jinsoo Hong, Victor W Pike, Wei Liu

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chao Wang *Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA.ORCID 0009-0009-0488-1670
Paul DeMent *Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Susovan JanaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9910-347X
Jinsoo HongMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0450-6258
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9032-2553
Wei LiuDepartment of Chemistry, University of Cincinnati, Cincinnati, OH, USA.ORCID 0000-0001-6249-3179

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
New Strategies for Copper-Catalyzed Cross-Coupling of Alkyl ElectrophilesR35GM146765 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Wei Liu · 2022 to 2026
$2.0M
Novel Approaches to 11C- and 18F-Trifluoromethylation for PET Tracer DevelopmentR01EB036046 · NIBIB · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Wei Liu · 2025 to 2026
$685k
Intramural NIH HHS ZIA MH002793NIBIB NIH HHS R01 EB036046NIGMS NIH HHS R35 GM146765
6 · The paper itself

Abstract

Continued development of positron emission tomography (PET) tracers is essential for advancing molecular imaging in biomedical research and clinical diagnostics. A long-standing limitation in radiochemistry for PET imaging has been the lack of general methods for radiolabeling trifluoromethyl (CF

Indexed as

Carbon RadioisotopesChlorofluorocarbons, MethaneFluorine RadioisotopesIsotope LabelingMolecular ImagingPositron-Emission TomographyRadiopharmaceuticalsCatalysisCopperHumansMethylationCarbon-11Carbon RadioisotopesChlorofluorocarbons, MethaneCopperFluorine-18Fluorine RadioisotopesfluoroformRadiopharmaceuticals

Identifiers

PMID41411425
PMCPMC12731722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.