ReviewExperimental physiology2025
Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline.
Review in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Increased Disarray of Extracellular Matrix Collagen-I Fiber Network and Compromised Biomechanics in Aortae From Marfan-Syndrome Mice Assessed Through Combined Opto-Biomechatronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026Review
- Attenuated aortic-cerebral pulsatile transmission with posture-related increases in stroke volume in healthy young adults.European journal of applied physiology · 2026Article
- Vascular stiffness predicts plasma markers of neurodegeneration among older African Americans.The journal of prevention of Alzheimer's disease · 2026Observational
- Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline.Experimental physiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Central arterial stiffening, particularly of the proximal aorta, is increasingly recognised as a pivotal contributor to cardiovascular disease, dementia, and mild cognitive impairment. Loss of Windkessel function amplifies pulsatile pressure, reduces diastolic perfusion and accelerates microvascular damage in the brain. Evidence from epidemiological studies, magnetic resonance imaging investigations and longitudinal data demonstrates disproportionate age-related stiffening of the proximal aorta and its strong association with cognitive decline. Importantly, this process is modifiable: aerobic exercise and unique environmental adaptations, such as those observed in Japanese Ama divers, preserve proximal aortic elasticity. Targeting central arterial stiffness may represent a promising strategy for preventing both vascular disease and brain dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.