ArticleActa parasitologica2025
n-Butanol Fraction of Dioscorea dumetorum Tuber Aqueous Extract Exhibited Potent Antimalarial Activity in Plasmodium berghei-infected Mice.
Article in Acta parasitologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeDioscorea dumetorum (locally known as Esuru {Yoruba tribe of Nigeria}) has been claimed to be used in folk medicine for the management of malaria without information on the anti-plasmodial rich fraction. It is against this background that the current study was designed to provide information on the anti-plasmodial rich fraction of Dioscorea dumetorium tubers.
methodsThe n-hexane (nHF), ethylacetate (EAF), and n-butanol (nBF) fractions obtained from D. dumetorum tubers were screened for anti-plasmodial activity. The most potent fraction, nBF, was further subjected to column chromatography and the resulting three sub-fractions (CCF1-CCF3) were equally screened for anti-plasmodial activity. The most potent sub-fraction, CCF1, was chemically profiled using HPLC.
resultsThe results revealed that the nBF and CCF1 demonstrated the most profound inhibition (p < 0.05) of parasite growth by 49.13% and 40.80% respectively. The CCF1contained 11 chemical compounds with allantoin and protodioscin being relatively the most abundant. The significant and dose-dependent suppression of parasitemia by the n-BF and its CCF1 in the murine model conferred potent anti-plasmodial activity on them.
conclusionIn conclusion, the nBF and CCF1 from the D. dumetorum tubers represents a promising and pharmacologically relevant source for the development of novel antimalarial therapies or lead compounds.
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