Evidence map›Paper›PMID 41410893›Full record

ArticleClinical and experimental medicine2025

New inflammatory markers associated with disease activity in patients with antineutrophil cytoplasmic Antibody-associated vasculitis.

Bowei Cao, Ningjie Zhang, Yuanpei Zhu, Weiwei Hao, Fang Dong, Rui Liu, Yongjun Wang, Wei Li

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In one paragraph

Article in Clinical and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Bowei Cao *Department of Blood Transfusion, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan Province, China.
Ningjie Zhang *Department of Blood Transfusion, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan Province, China.
Yuanpei ZhuDepartment of Blood Transfusion, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan Province, China.
Weiwei HaoDepartment of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan Province, China.
Fang DongDepartment of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan Province, China.
Rui LiuDepartment of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan Province, China.
Yongjun WangDepartment of Blood Transfusion, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan Province, China. wangyongjun@csu.edu.cn.
Wei LiDepartment of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan Province, China. libuwei2011@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives To explore the relationship between the levels of new inflammatory markers (MLR, PLR, NLR, SII and SIRI) and the disease activity in patients with antineutrophil cytoplasmic antibody-associated vasculitis. Patients and methods In this study, 974 patients with AAV were included. On the basis of the Birmingham vasculitis activity score (BVAS), the patients were divided into high-disease-activity (BVAS ≥ 12) and low-disease-activity (BVAS < 12) groups. The new inflammatory markers in the two groups were compared. Multivariate linear regression analysis was performed to assess the influencing factors of disease activity in patients with AAV. Results The levels of MLR, NLR, PLR, SII, and SIRI in the high-disease-activity group significantly increased (P < 0.05) compared with those in the low-disease-activity group, and some indictors (SII and SIRI) recovered after AAV disease-inducing remission. Furthermore, the MLR, NLR, SII, SIRI, and BVAS of the patients with AAV with renal involvement significantly increased (P < 0.05). Spearman correlation analysis showed that these new inflammation markers were positively correlated with BVAS and traditional inflammatory markers, such as C-reactive protein and erythrocyte sedimentation rate (all P < 0.001). Multivariate linear regression analysis revealed that MLR, NLR and SIRI were independent risk factors for high disease activity (P < 0.05). Conclusion These nonspecific inflammatory indicators, derived from routine blood tests, may serve as potential supportive markers for assessing disease activity in patients with AAV.

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisBiomarkersInflammationAdultAgedC-Reactive ProteinFemaleHumansMaleMiddle AgedSeverity of Illness IndexBiomarkersC-Reactive ProteinANCA-associated vasculitisDisease activityInflammatory markerSystemic inflammatory response index

Identifiers

PMID41410893
PMCPMC12774929

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