Evidence map›Paper›PMID 41410821›Full record

ArticleBiological trace element research2026

Associations of Paternal Seminal Plasma Metals with their Spouses' Unexplained Recurrent Spontaneous Abortion (URSA) Risk and the Potential Mediating Role of Oxidative Stress.

Hanyan Xi, Rui Yang, Huaqiong Bao, Huiru Li, Youzhu Li, Francis L Martin, Wei Chen, Liang Chen, Yan Sun, Yan-Yang Lu and 2 more

Abstract read
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In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hanyan Xi *State Key Laboratory for Ecological Security of Regions and Cities, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
Rui Yang *Center of Reproductive Medicine, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, 350001, China.
Huaqiong BaoNHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, 400020, China. baohuaqiong@163.com.
Huiru LiState Key Laboratory for Ecological Security of Regions and Cities, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
Youzhu LiDepartment of Reproductive Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, 361005, China.
Francis L MartinClinical Research Centre, Blackpool Teaching Hospitals NHS Foundation Trust Blackpool Victoria Hospital, Blackpool, FY3 8NR, UK.
Wei ChenDepartment of Reproductive Medicine, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, 361005, China.
Liang ChenNHC Key Laboratory of Birth Defects and Reproductive Health, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, 400020, China.
Yan SunCenter of Reproductive Medicine, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, Fuzhou, 350001, China.
Yan-Yang LuState Key Laboratory for Ecological Security of Regions and Cities, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
Qingyu HuangState Key Laboratory for Ecological Security of Regions and Cities, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
Meiping TianState Key Laboratory for Ecological Security of Regions and Cities, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China. mptian@iue.ac.cn.

Funding

National Natural Science Foundation of China 22376195
6 · The paper itself

Abstract

Unexplained recurrent spontaneous abortion (URSA) is a prevalent reproductive issue but its etiology remains obscure. Male exposure to environmental chemicals is suggested to elevate URSA risk in female partners. Herein, a case-control design set out to investigate associations between metal levels in human seminal plasma with URSA risk, plus to determine evidence of mediating effects by oxidative stress. Levels of 15 metal elements and oxidative stress marker malondialdehyde (MDA) in seminal plasma were measured in 125 male spouses of URSA cases compared to 108 male partners of women with successful pregnancy outcomes. The associations of single or mixed metals on URSA risk were analyzed using logistic regression and Bayesian kernel machine regression (BKMR), respectively. BKMR analyses reveal a joint effect of metal co-exposures on URSA risk. Through multiple statistical approaches, titanium (Ti), cadmium (Cd) or magnesium (Mg) were major contributors to metal mixtures elevating URSA risk. MDA was significantly and positively associated with URSA risk. Mediation analysis shows that the associations of Ti, Cd or Mg with URSA risk appear to be mediated by MDA at rates of 23.30%, 16.26% or 34.48%, respectively. In vitro experiments confirmed the seminal plasma relevant dose Ti, Cd or Mg exposure induced male mouse spermatocyte-derived GC-2 cells oxidative stress. Metal mixtures in seminal plasma are associated with increased URSA risk in female spouses, with Ti, Cd or Mg being significant contributors, potentially via oxidative stress, providing further insights into URSA etiology.

Indexed as

Abortion, HabitualAbortion, SpontaneousOxidative StressSemenSpousesAdultAnimalsCase-Control StudiesFemaleHumansMaleMalondialdehydeMicePregnancyRisk FactorsMalondialdehydeJoint effectsMalondialdehydeMetalsMixed exposure analysisOxidative stressSeminal fluidUnexplained recurrent spontaneous abortion

Identifiers

PMID41410821

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.