Evidence map›Paper›PMID 41410819›Full record

ReviewCurrent neurology and neuroscience reports2025

Early-Onset Parkinson's Disease: Unique Features and Management Approaches.

Jordan Hickman, Andrew Tsai, Michelle Fullard, Michael Korsmo, Emily Forbes, Sana Aslam, Alexander J Baumgartner, Jeanne S Feuerstein, Ece Bayram

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. What's in a name? reframing advanced Parkinson's disease as a multidimensional state.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  3. Article
  4. Global, regional, and national burden of Early-onset Parkinson's disease: A comprehensive analysis and forecast, 1990-2021.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jordan HickmanUniversity of Colorado Anschutz Medical Campus, Medical Scientist Training Program, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-9048-2247
Andrew TsaiUniversity of California Los Angeles, The UCLA Institute for Society and Genetics, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0002-4383-8893
Michelle FullardMovement Disorders Center, Department of Neurology, University of Colorado Anschutz, 12469 E 19th Ave, Aurora, CO, 80045, USA.ORCID http://orcid.org/0000-0002-8749-2487
Michael KorsmoMovement Disorders Center, Department of Neurology, University of Colorado Anschutz, 12469 E 19th Ave, Aurora, CO, 80045, USA.ORCID http://orcid.org/0009-0007-4960-4218
Emily ForbesMovement Disorders Center, Department of Neurology, University of Colorado Anschutz, 12469 E 19th Ave, Aurora, CO, 80045, USA.ORCID http://orcid.org/0000-0003-2372-0126
Sana AslamMovement Disorders Center, Department of Neurology, University of Colorado Anschutz, 12469 E 19th Ave, Aurora, CO, 80045, USA.ORCID http://orcid.org/0000-0002-7391-7421
Alexander J BaumgartnerDepartment of Neurosurgery, University of Colorado, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-0009-2756
Jeanne S FeuersteinDepartment of Neurology, Rocky Mountain Regional VA Medical Center, Aurora, CO, USA.ORCID http://orcid.org/0000-0002-7701-3120
Ece BayramMovement Disorders Center, Department of Neurology, University of Colorado Anschutz, 12469 E 19th Ave, Aurora, CO, 80045, USA. ece.bayram@cuanschutz.edu.ORCID http://orcid.org/0000-0002-6875-4242

Funding

Interrogating the propagation of electrical stimulation across scales in vivoR01NS120850 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DENMAN, DANIEL JAMES · 2021 to 2025
$2.6M
Genetic and Neuropathologic Underpinnings of Sex Differences in Lewy Body DementiasR00AG073453 · NIA · UNIVERSITY OF COLORADO DENVER · PI ECE BAYRAM · 2024 to 2026
$725k
NIA NIH HHS R00 AG073453NIA NIH HHS R00AG073453NINDS NIH HHS R01 NS120850NINDS NIH HHS R01NS120850
6 · The paper itself

Abstract

purpose of reviewTo highlight the unique clinical features, risk factors, and management strategies associated with early-onset Parkinson's disease (EOPD), and contrast these with late-onset Parkinson's disease (LOPD). We outline how these differences influence diagnostic and therapeutic approaches and identify key knowledge gaps critical to improving clinical care. RECENT

findingsCompared to LOPD, EOPD (onset age 21-50) has a higher prevalence of monogenic risk factors, focal dystonia, depression, anxiety; slower motor progression; lower rates of cognitive decline; higher risk for delayed diagnosis. Treatment is complicated by earlier and more frequent dyskinesias, motor fluctuations, and unique considerations such as pregnancy and career impact. Risk factors, clinical presentation, progression, and management needs of EOPD can differ from LOPD. Despite advances in characterizing and diagnosing EOPD, most research remains focused on LOPD. There is a critical need to tailor research and clinical trials to address the distinct needs of people with EOPD.

Indexed as

Parkinson DiseaseAge of OnsetDisease ManagementDisease ProgressionHumansRisk FactorsBiomarkerClinical featuresDiagnosisEarly onset parkinson diseaseRisk factorsTreatment

Identifiers

PMID41410819
PMCPMC12714827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.