Evidence map›Paper›PMID 41410805›Full record

ReviewJournal of assisted reproduction and genetics2026

The roles of RNA-binding proteins in ovarian aging.

Hanyue Zhang, Han Pan, Tianying Zheng, Chen Dou, Yuan Geng, Jing Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hanyue Zhang *Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, No. 100 Science Avenue, Zhengzhou, 450001, China.
Han Pan *Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, No. 100 Science Avenue, Zhengzhou, 450001, China.
Tianying Zheng *Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, No. 100 Science Avenue, Zhengzhou, 450001, China.
Chen DouDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, No. 100 Science Avenue, Zhengzhou, 450001, China.
Yuan GengThe First Clinical School of Medicine, Zhengzhou University, Erqi District, No. 40, Daxue North Road, Zhengzhou, 450001, China.
Jing ChenThe Third Clinical School of Medicine, Zhengzhou University, Erqi District, No. 40, Daxue North Road, Zhengzhou, 450001, China. jchenbc@zzu.edu.cn.

Funding

He'nan Postdoctoral Science Foundation, He'nan Science and technology foundation 252102311106Innovation Central Plains of Henan Association for Science and Technology 2025HYTP093National Natural Science Foundation of China 82201836
6 · The paper itself

Abstract

The higher incidence of ovarian aging has led to a significant decline in the female fertility rate, raising social concerns about women's health. In recent years, the rapid development of RNA cross-linked proteomics technology has identified the role of RNA-binding proteins (RBPs) in ovarian aging. Ovarian aging disrupts the hypothalamic-pituitary-ovarian axis, resulting in aberrant hormone secretion, irregular menstrual cycles, oocyte apoptosis, and abnormal embryonic development. Given this, we have compiled the role of RNA-binding proteins in ovarian aging and further explored how different ovarian RBPs promote apoptosis and serve as therapeutic targets. We aim to analyze the effects of RNA-binding proteins on ovarian function to provide more explicit ideas for delaying ovarian aging and treating ovarian diseases.

Indexed as

AgingOvaryRNA-Binding ProteinsApoptosisFemaleHumansOocytesRNA-Binding ProteinsOvarian agingOvarian diseasesRNA-binding proteinsTherapeutic targets

Identifiers

PMID41410805
PMCPMC12901777

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.