Evidence map›Paper›PMID 41410480›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Dispersion-Enhanced Nitrogen-Centered Photocatalysis of the Direct Hydrogen Atom Transfer.

Jiasong Zhang, Kaitong Zhuang, Ramon Trevino, Babu Raj Dhungana, Huiying Sun, Shuyu Yin, Yuting Li, Jacob A Sanchez, Xiaoyu Xia, Ramy Elerian and 7 more

Abstract read
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In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiasong Zhang *Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
Kaitong Zhuang *Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
Ramon Trevino *Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Babu Raj Dhungana *Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Huiying SunWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
Shuyu YinWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
Yuting LiWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
Jacob A SanchezDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Xiaoyu XiaWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
Ramy ElerianDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Yao SunWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
Seth O FreminDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Chao HuangWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
Min HeWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
Maosheng ChengKey Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.
Oleg V LarionovDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.ORCID https://orcid.org/0000-0002-3026-1135
Shengfei JinWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P.R. China.

Funding

Basic Research Project of Liaoning Provincial Department of Education LJ212410163039Joint Project of Liaoning Science and Technology 2024-MSLH-437Liaoning Revitalization Talents Program XLYC2203143National Natural Science Foundation of China 22101187National Science Foundation CHE-2102646
6 · The paper itself

Abstract

The development of structurally distinct and modular photocatalysts for direct hydrogen atom transfer (HAT) has emerged as a key frontier in radical-mediated C-H functionalization of strong carbon-hydrogen bonds. Despite the largely untapped potential across the fields of organic synthesis, medicinal chemistry, and materials science, few classes of direct HAT photocatalysts are currently known, and the approaches to enhancing their photocatalytic activity remain underdeveloped. We report herein the development of nitrogen-centered direct HAT photocatalysts based on the acridine framework, which leverage a C9-ortho-biaryl substituent for enhancing the photocatalytic activity through stabilizing dispersion interactions with the substrate as the key steering effect. The acridine direct HAT photocatalysis enables an array of carbon-carbon and carbon-heteroatom bond-forming reactions in diverse structural and experimental settings, including cryogenic conditions. It also provides a blueprint for enhancing the photocatalytic activity of direct HAT catalysts by leveraging photocatalyst-substrate dispersion interactions.

Indexed as

AcridineHydrogen atom transferNoncovalent interactionsPhotocatalysisRadical reactions

Identifiers

PMID41410480
PMCPMC12865266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.