Evidence map›Paper›PMID 41410464›Full record

ArticleSexually transmitted diseases2026

Tetracycline Resistance Among Neisseria gonorrhoeae Isolates-United States, 1987-2022.

Sarah Wondmeneh, Emily R Learner, Matthew W Schmerer, Alesia Harvey, Kerry Mauk, John R Papp, Laura A S Quilter, Sancta B St Cyr, Antimicrobial-Resistant Neisseria gonorrhoeae Working Group

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Article in Sexually transmitted diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Sarah WondmenehFrom the Epidemic Intelligence Service, National Center for State, Tribal, Local and Territorial Public Health Infrastructure and Workforce.ORCID 0000-0003-0097-7770
Emily R LearnerDivision of STD Prevention, National Center for HIV, Viral Hepatitis, STD and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Matthew W SchmererDivision of STD Prevention, National Center for HIV, Viral Hepatitis, STD and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Alesia HarveyDivision of STD Prevention, National Center for HIV, Viral Hepatitis, STD and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Kerry MaukDivision of STD Prevention, National Center for HIV, Viral Hepatitis, STD and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
John R PappDivision of STD Prevention, National Center for HIV, Viral Hepatitis, STD and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Laura A S QuilterDivision of STD Prevention, National Center for HIV, Viral Hepatitis, STD and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Sancta B St CyrDivision of STD Prevention, National Center for HIV, Viral Hepatitis, STD and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Antimicrobial-Resistant Neisseria gonorrhoeae Working Group

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundDoxycycline use in sexually transmitted infection (STI) care is changing. Concerns about antimicrobial resistance (AR) have accompanied recent recommendations for doxycycline as bacterial STI postexposure prophylaxis (doxy PEP). We describe trends in tetracycline resistance (TetR) among Neisseria gonorrhoeae (GC) isolates collected through US national surveillance in anticipation of expanded use of doxy PEP.

methodsN. gonorrhoeae isolates were collected from men with symptomatic urethritis attending Gonococcal Isolate Surveillance Project (GISP) clinics during 1987-2022 or from patients diagnosed with gonorrhea attending GISP, enhanced GISP, and/or Strengthening the US Response to Resistant Gonorrhea clinics during 2018-2022. Antimicrobial susceptibility testing was performed using agar dilution. We describe TetR (tetracycline minimum inhibitory concentration (MIC) ≥2 μg/mL) and high-level TetR (TetHLR) (MIC ≥16 μg/mL) patterns among collected GC isolates, including by sex and sex of sex partner(s).

resultsA total of 183,668 urethral GC isolates were collected from men with symptomatic urethritis during 1987-2022. The proportion of isolates demonstrating TetR was stable during 1987 (19.7%) to 2022 (19.7%) though isolates demonstrating TetHLR increased from 2.8% to 14.6%. A total of 38,383 GC isolates were collected from patients with gonorrhea during 2018-2022; TetHLR increased across all sex/sex of sex partner(s) groups and was highest among men reporting male sex partner(s).

conclusionsAn increasing proportion of GC isolates collected through US national surveillance are demonstrating TetHLR. As doxycycline use expands in STI care, enhanced surveillance will be needed to monitor downstream impacts of its use on antimicrobial-resistant GC.

Indexed as

Anti-Bacterial AgentsGonorrheaNeisseria gonorrhoeaeTetracycline ResistanceAdultDoxycyclineFemaleHumansMaleMicrobial Sensitivity TestsSexual PartnersTetracyclineUnited StatesUrethritisYoung AdultAnti-Bacterial AgentsDoxycyclineTetracycline

Identifiers

PMID41410464
PMCPMC13037608

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