ArticleJournal of clinical microbiology2026
Quantification and diagnostic relevance of blood and heme-mediated inhibition of prion detection by RT-QuIC.
Article in Journal of clinical microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- CWD prions are present in the blood of healthy-appearing, naturally infected free-ranging white-tailed deer.Scientific reports · 2026Article
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2 authors.
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Abstract
Prion diseases are characterized by misfolding of prion protein (PrP) from correctly folded PrP IMPORTANCE: Real-time quaking-induced conversion (RT-QuIC) is an ultrasensitive amplification assay for the detection of prions. The assay has shown exceptional performance in optimal laboratory conditions, on par with bioassay, and far surpassing current immunoassay diagnostics. However, efforts to apply RT-QuIC as a real-world diagnostic have been hampered by inconsistencies and unexpectedly low sensitivity in some field samples. This study aims to quantify and characterize the mechanism of inhibition from blood and its constituent parts, hemoglobin and heme-omnipresent components of most sample types. Such systematic evaluations of RT-QuIC inhibitory factors represent necessary steps toward the consistent and sensitive performance necessary for a field-applicable diagnostic assay.
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