ArticleThe Journal of infectious diseases2026
The Pandemic Respiratory Virus Epidemiological Surveillance Trial - A Self-swab Surveillance System for Respiratory Viruses Nested Within FluTracking.
Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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17 authors.
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Abstract
backgroundThe COVID-19 pandemic has underscored the importance of effective surveillance and early warning systems for respiratory viruses, but most current surveillance data focus on symptomatic individuals visiting healthcare facilities. Symptomatic and asymptomatic virus transmission in the community can both play major roles in the spread of respiratory outbreaks. We aimed to assess the feasibility of monitoring symptomatic and asymptomatic respiratory virus infection in a sample of community dwelling volunteers.
methodsThe Pandemic Respiratory Virus Epidemiological SurveillaNce Trial was nested within the ongoing FluTracking platform, which involves community-dwelling adults filling in a weekly online respiratory symptom survey. We recruited 52 FluTracking participants living in one Australian city to self-collect weekly nasal swabs and return them via post for a 50-week period. All swabs were tested for the presence of respiratory viruses using a 16-plex PCR panel. Results were correlated with weekly symptom surveys.
resultsA total of 2068 nasal swabs were received, corresponding to an 84% swab collection and return rate. Fifty-five samples (3.0%) were discarded due to delayed postage or sample leakage. At least one sample tested positive for virus in 231 of 2013 participant-weeks (11.0%), with 24.2% of these detections being in asymptomatic individuals. Rhinovirus (57.6% of positive swabs) and SARS-COV-2 (20.3% of positive swabs) were the most frequently detected viruses.
conclusionsRegular self-collected nasal swabs for detecting respiratory viruses in a community setting is feasible in Australia and provides valuable information on asymptomatic infection.
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