ArticlemBio2026
Gasdermin B-mediated pyroptosis as a host defense against swine enteric coronaviruses and its antagonism by PEDV.
Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Coronavirus Nsp5‑mediated dual‑site cleavage of GSDMA modifies its antiviral and proinflammatory functions.PLoS pathogens · 2026Article
- Molecular Epidemiology, Mating Types, Clinical, and Physiological traits of Microsporum canis in Humans and Companion Animals (Cats and Dogs) in the Guiyang Region, Southwest China.Mycopathologia · 2026Article
- Novel bacteriophages effectively target multidrug-resistant clinical isolates of Klebsiella pneumoniae.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gasdermin B (GSDMB), a member of the spore-forming protein gasdermin (GSDM) family, is critical for inflammation and immunity and has been genetically linked to human diseases. Despite its prominent expression at mucosal surfaces, including the gastrointestinal and respiratory tracts, GSDMB's role in defending against viral pathogens at these barrier tissues remains poorly defined. Here, we reveal that porcine GSDMB (pGSDMB), which is highly expressed in the intestinal epithelium, is a potent innate restriction factor against porcine epidemic diarrhea virus (PEDV), a major enteric coronavirus. Mechanistically, PEDV infection activated caspase-3/6/7 to cleave pGSDMB at D237, generating an active N-terminal fragment (pGSDMB
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.