Evidence map›Paper›PMID 41410397›Full record

ReviewVirulence2026

Small regulatory RNAs mediated regulation of virulence and host-pathogen interaction in the Gram-negative ESKAPE pathogens.

Lifeng Li, Zhenkun Zhang, Hongrui Zhu, Kefeng Cui, Xiaorui Song, Zhaobao Wang, Linxu Chen, Zhidan Yu, Wancun Zhang, Huiqing Sun and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Virulence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lifeng LiDepartment of Neonatology, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital,Zhengzhou, China.ORCID 0000-0002-7573-2367
Zhenkun ZhangDepartment of Neonatology, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital,Zhengzhou, China.
Hongrui ZhuDepartment of Neonatology, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital,Zhengzhou, China.
Kefeng CuiDepartment of Neonatology, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital,Zhengzhou, China.
Xiaorui SongDepartment of Neonatology, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital,Zhengzhou, China.ORCID 0000-0001-6225-1516
Zhaobao WangEnergy-Rich Compounds Production by Photosynthetic Carbon Fixation Research Center, Shandong Key Lab of Applied Mycology, College of Life Sciences, Qingdao Agricultural University, Qingdao, China.
Linxu ChenState Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
Zhidan YuDepartment of Neonatology, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital,Zhengzhou, China.
Wancun ZhangDepartment of Neonatology, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital,Zhengzhou, China.
Huiqing SunDepartment of Neonatology, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital,Zhengzhou, China.ORCID 0000-0002-1600-2663
Zengyuan YuDepartment of Neonatology, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital,Zhengzhou, China.
Yitao DuanDepartment of Laboratory Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Mingchao LiDepartment of Neonatology, Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital,Zhengzhou, China.ORCID 0000-0001-7395-9982

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence and global spread of antimicrobial resistant (AMR) pathogens represent a critical challenge to global public health security. The ESKAPE pathogens refer to a group of highly troublesome multidrug-resistant bacteria responsible for hospital-acquired infections. Of particular concern are Gram-negative ESKAPE pathogens, which pose a significant threat to patient health and healthcare systems worldwide. Systematic investigation into antimicrobial resistance mechanisms and pathogenicity regulation is therefore imperative for developing effective infection control strategies. Emerging evidence highlights small regulatory RNAs (sRNAs) as pivotal post-transcriptional modulators in bacterial physiology, particularly in governing virulence determinant expression and host-pathogen interactions during infection. This review summarizes recent advances in sRNA-mediated regulatory mechanisms in Gram-negative ESKAPE pathogens, with emphasis on

Indexed as

Gene Expression Regulation, BacterialGram-Negative BacteriaHost-Pathogen InteractionsRNA, BacterialRNA, Small UntranslatedAcinetobacter baumanniiDrug Resistance, Multiple, BacterialGram-Negative Bacterial InfectionsHumansKlebsiella pneumoniaePseudomonas aeruginosaVirulenceVirulence FactorsRNA, BacterialRNA, Small UntranslatedVirulence Factorscis-encoded and trans-encodedESKAPE pathogenssRNAtherapeutic targetsvirulence

Identifiers

PMID41410397
PMCPMC12716042

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.