Asymmetric Hydride Shift Reactions Catalyzed by Chiral Aluminium Complexes.

Mostafa M Amer, Jingyan Hou, Jinfang Wang, Akvile Mazeikaite, Timothy J Donohoe

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Asymmetric Hydride Shift Reactions Catalyzed by Chiral Aluminium Complexes.Angewandte Chemie (International ed. in English) · 2026
Article

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mostafa M Amer *Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

Jingyan Hou *Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

Jinfang WangDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

Akvile Mazeikaite *Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

Timothy J DonohoeDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.ORCID https://orcid.org/0000-0001-7088-6626

Funding

EPSRC EP/V028995/1EPSRC EP/W02246X/1Lithuanian State Studies Foundation

6 · The paper itself

Abstract

An asymmetric intramolecular hydride shift reaction has been developed that is catalyzed by Al Lewis acids in conjunction with a chiral BINOL-derived ligand. Racemic THP substrates are transformed into cyclohexene products via a prochiral intermediate ring opened enone; which then undergoes a key 1,5-hydride shift reaction. This reaction is operationally simple, works well on a gram scale, and the desired products are formed with very high enantioselectivity (up to >98:2 e.r.). Importantly, the cyclohexene products contain functionality that can be easily derivatized and this is exemplified in the paper. Finally, a model is presented for the enantioselective hydride shift that is based on previous DFT studies.

Indexed as

AldolAluminiumAsymmetric synthesisCyclohexenesHydride shift

Identifiers

PMID41410305

DOI10.1002/anie.202521374

PMCPMC12850996

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