Evidence map›Paper›PMID 41410197›Full record

ArticleAllergy2026

Cost-Effectiveness of Venom Immunotherapy in Preventing Severe Bee and Wasp Sting Reactions.

Gunter Sturm, Maria Beatrice Bilò, Carmen Vidal, Joanna N G Oude Elberink, Jochen Schmitt, Andreas Kallsoy Slættanes, Thilo Jakob

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gunter SturmDepartment of Dermatology and Venereology, Medical University of Graz, Graz, Austria.ORCID https://orcid.org/0000-0002-7245-121X
Maria Beatrice BilòDepartment of Clinical and Molecular Sciences, Università Politecnica Delle Marche, Ancona, Italy.ORCID https://orcid.org/0000-0002-9324-6039
Carmen VidalAllergy Department, Complejo Hospitalario Universitario de Santiago, Faculty of Medicine USC, Santiago de Compostela, Spain.ORCID https://orcid.org/0000-0002-2844-2754
Joanna N G Oude ElberinkDepartment of Allergology, University Medical Center Groningen, University of Groningen, and Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands.ORCID https://orcid.org/0000-0003-2844-2196
Jochen SchmittCenter for Evidence-Based Healthcare, TU Dresden, Dresden, Germany.ORCID https://orcid.org/0000-0003-0264-0960
Andreas Kallsoy SlættanesALK-Abelló A/S, Hørsholm, Denmark.
Thilo JakobDepartment of Dermatology and Allergy, University Medical Center, Justus-Liebig University, Gießen, Germany.ORCID https://orcid.org/0000-0002-3124-9998

Funding

ALK-Abelló
6 · The paper itself

Abstract

backgroundSystemic sting reactions (SSRs) from bee and wasp stings can cause severe symptoms, including anaphylaxis and potentially lead to fatal outcomes. These reactions can significantly affect individuals' daily lives due to the fear and anxiety associated with the risk of stings. Venom immunotherapy (VIT) has been shown to be an effective preventive treatment for SSRs, offering a viable alternative to emergency treatments like adrenaline auto-injectors (AAIs).

methodsWe created a decision tree framework with a Danish payer perspective designed to evaluate the cost-effectiveness of VIT with Alutard

resultsIn the base case, the incremental cost of HVDI was €7428, while the incremental quality-adjusted life years (QALYs) gained were 0.48. Consequently, the ICER (cost per QALY) of HVDI compared to AAIs after 10 years was estimated at €15,550.

conclusionVIT is a cost-effective treatment for the prevention of severe reactions to wasp and/or bee stings when compared to AAIs.

Indexed as

AnaphylaxisBee VenomsDesensitization, ImmunologicInsect Bites and StingsWasp VenomsAnimalsBeesCost-Benefit AnalysisHumansQuality-Adjusted Life YearsWaspsBee VenomsWasp Venomsimmunotherapy vaccines and mechanismsquality of lifevenom and insect allergy

Identifiers

PMID41410197
PMCPMC13040657

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.