Evidence map›Paper›PMID 41410169›Full record

ArticleEuropean journal of immunology2025

Ultrasensitive Test Systems Are Required to Quantify Interferon Alpha Protein in Serum Samples.

Liis Haljasmägi, Sandra Meisalu, Vincent Bondet, Pärt Peterson, Darragh Duffy, Kai Kisand

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liis HaljasmägiInstitute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Sandra MeisaluDepartment of Rheumatology, East Tallinn Central Hospital, Tallinn, Estonia.
Vincent BondetTranslational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France.ORCID 0000-0002-6534-0984
Pärt PetersonInstitute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0001-6755-791X
Darragh DuffyTranslational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France.ORCID 0000-0002-8875-2308
Kai KisandInstitute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0002-5426-4648

Funding

Eesti Teadusagentuur PRG1117European Union through HORIZON Coordination and Support Actions 101159920
6 · The paper itself

Abstract

Selecting a sensitive test system is crucial to measure IFNα in serum samples. Simoa digital ELISA stands out for its high sensitivity and strong correlation with transcript-based IFN-induced gene (ISG) scores. In SLE, the ISG score is explained by circulating IFNα levels with negligible contribution from IFNβ or IFNγ. Created in BioRender.

Indexed as

Interferon-alphaLupus Erythematosus, SystemicEnzyme-Linked Immunosorbent AssayHumansInterferon-gammaSensitivity and SpecificityInterferon-alphaInterferon-gammaELISAIFN‐stimulated genesIFNαSimoaSLE

Identifiers

PMID41410169
PMCPMC12712876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.