Evidence map›Paper›PMID 41410161›Full record

ArticleEuropean journal of immunology2025

Selection and Characterisation of Minor Histocompatibility Antigen-Specific Regulatory T Cells in Fully HLA-Matched Setting for GVHD Therapy.

Carolina Paulino Pacini, Rita I Azevedo, Luís Ramalhete, Hugo A J Lainé, Maria V D Soares, João F Lacerda

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carolina Paulino PaciniJLacerda Lab, Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.ORCID 0000-0002-3562-0213
Rita I AzevedoJLacerda Lab, Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.ORCID 0000-0002-5534-1481
Luís RamalheteBlood and Transplantation Center of Lisbon, Instituto Português do Sangue e da Transplantação, Lisbon, Portugal.ORCID 0000-0002-8911-3380
Hugo A J LainéAdvanced Data Analysis, Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.ORCID 0009-0005-6297-1528
Maria V D SoaresJLacerda Lab, Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.ORCID 0000-0002-6492-2931
João F LacerdaJLacerda Lab, Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.ORCID 0000-0003-1351-2809

Funding

Fundação para a Ciência e Tecnologia 2022.12709.BDFundação para a Ciência e Tecnologia PTDC/MEC-HEM/5281/2020la Caixa LCF/BQ/DI19/11730053
6 · The paper itself

Abstract

Graft-versus-host disease is mediated by donor-derived T cells reactive against the recipient's broadly expressed minor histocompatibility antigens (mHA). Regulatory T cells (Treg) have been explored as a therapeutic approach for chronic GVHD (cGVHD). The promising results from polyclonal Treg trials in this setting have led us to develop a Treg product specific for mismatched minor antigens between patient and donor (mTreg), circumventing broad immune suppression risks. HLA-matched siblings of opposite sexes were used to obtain the sister's CD4

Indexed as

Graft vs Host DiseaseMinor Histocompatibility AntigensT-Lymphocytes, RegulatoryCoculture TechniquesDendritic CellsFemaleHistocompatibility TestingHumansMaleMinor Histocompatibility Antigensantigen‐specific TregcGVHDHLA class IIHLA‐matchedmHA

Identifiers

PMID41410161
PMCPMC12712890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.