ArticleCureus2025
Chronic Rhinosinusitis With Nasal Polyps Successfully Treated With Tezepelumab After an Inadequate Response to Dupilumab: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Use of Biological Therapies in the Treatment of Chronic Rhinosinusitis with Nasal Polyps: Current State of Knowledge.Journal of clinical medicine · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease that is often refractory to surgery and requires treatment with biologics, including dupilumab (DUP), a monoclonal antibody targeting IL-4/13. We report a case of severe CRSwNP with comorbid severe asthma that showed unfavorable outcomes with DUP treatment but markedly responded to tezepelumab (TEZ), a monoclonal antibody targeting thymic stromal lymphopoietin (TSLP). A 41-year-old man with steroid-dependent intractable asthma and CRSwNP presented with anosmia and nasal obstruction. Although the patient had undergone functional endoscopic sinus surgery (FESS) and subsequently received systemic corticosteroids (SCSs) and DUP therapy (prescribed by respiratory medicine clinicians), the nasal obstruction and anosmia persisted, and nasal polyps continued to enlarge. Owing to poor control of asthma, the Department of Respiratory Medicine switched the systemic therapy to TEZ. Four months after TEZ initiation, asthma control improved along with reductions in the nasal polyp score (NPS) and computed tomography scores. Notably, olfaction improved from anosmia to mild hyposmia within one year. SCSs were successfully discontinued without asthma exacerbation. TSLP, which acts upstream of IL-4/13 in the type 2 inflammation cascade, may be a promising therapeutic option for patients with CRSwNP and comorbid asthma refractory to DUP. Further studies are warranted to validate the efficacy of TEZ in the management of CRSwNP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.