ArticleCureus2025
Navigating a Dual Challenge: Management of Advanced Ovarian Cancer Diagnosed During the Second Trimester.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Ovarian cancer during pregnancy is rare, and diagnosis is often delayed as symptoms overlap with normal pregnancy and tumour markers are unreliable. We present a case of a 31-year-old patient who presented at 21 weeks' gestation with bilateral pleural effusions and respiratory compromise. Pleural cytology confirmed metastatic carcinoma consistent with a gynaecologic primary. After multidisciplinary review, neoadjuvant chemotherapy with carboplatin and paclitaxel was initiated in the second trimester and continued into the third trimester. Foetal surveillance revealed appropriate growth with no adverse effects. Labour was induced at 37 weeks, resulting in vaginal delivery of a healthy infant. The patient subsequently underwent interval cytoreductive surgery three weeks postpartum, followed by adjuvant chemotherapy, and remains in remission. This case demonstrates that platinum-taxane chemotherapy can be safely administered in pregnancy with favourable maternal and neonatal outcomes.
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