ArticleCureus2025
The Silent Culprit: Drug-Induced Fever Associated With Trimethoprim-Sulfamethoxazole.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug-induced fever (DIF) is often misdiagnosed, particularly when it occurs alongside an infection. Its hallmark is the resolution of fever upon drug withdrawal and rapid recurrence upon re-exposure. Although five potential mechanisms have been proposed to explain this phenomenon, they remain poorly understood, making DIF a challenging diagnosis. We report a case of trimethoprim-sulfamethoxazole-induced drug fever, demonstrated by reproducible symptom onset following a drug provocation test, with supportive evidence from positive intradermal and lymphocyte transformation tests. The diagnosis of DIF requires a high degree of suspicion and the thorough exclusion of other causes of fever, such as infections or inflammatory conditions. Increased awareness and understanding of DIF are essential to improve diagnostic accuracy and patient outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.