Evidence map›Paper›PMID 41409860›Full record

ArticleSurgical neurology international2025

Revisiting the role of histopathology in acute intracerebral hemorrhage: Detecting missed secondary lesions beyond neuroimaging.

Tomoya Sofue, Megumi Chatani, Norio Miyoshi, Kenkichi Takahashi, Shinji Yamamoto, Yoshihiro Kuga, Hiroyuki Ohnishi, Hideyuki Ohnishi

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In one paragraph

Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tomoya SofueDepartment of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo, Japan.
Megumi ChataniDepartment of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo, Japan.
Norio MiyoshiDepartment of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo, Japan.
Kenkichi TakahashiDepartment of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo, Japan.
Shinji YamamotoDepartment of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo, Japan.
Yoshihiro KugaDepartment of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo, Japan.
Hiroyuki OhnishiDepartment of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo, Japan.
Hideyuki OhnishiDepartment of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Intracerebral hemorrhage (ICH) is commonly due to hypertension, but secondary causes such as vascular malformations and tumors may be radiographically occult. While advanced imaging has improved preoperative detection, some lesions remain undetected. This study reassessed the diagnostic value of routine histopathological analysis of hematoma specimens in such cases. Methods: We retrospectively reviewed 93 surgically treated ICH cases (2015-2024) with no preoperative suspicion of secondary etiology. All specimens underwent histopathological evaluation, and diagnostic yield was assessed. Results: Histopathology revealed secondary causes in 27 cases (29%): cerebral amyloid angiopathy ( Conclusion: Routine histopathological evaluation of hematoma specimens remains valuable in ICH surgery, even in the modern imaging era. This simple, low-burden practice identified otherwise occult etiologies in nearly one-third of cases and should be considered a standard adjunct to neuroimaging for accurate diagnosis and optimized care.

Indexed as

Arteriovenous malformationBrain tumorCavernous malformationDural arteriovenous fistulaIntracranial hemorrhagePathological evaluation

Identifiers

PMID41409860
PMCPMC12707751

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