ArticleSurgical neurology international2025
Unusual spontaneous resolution of a nonfunctioning pituitary macroadenoma: A case report.
Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Spontaneous regression of nonfunctioning pituitary macroadenomas is rare, typically linked to pituitary apoplexy caused by infarction or hemorrhage. Regression without apoplexy is exceptional and challenges the standard surgical approach. Case Description: We present a 24-year-old woman, 15 months postpartum, with progressive headaches and bitemporal hemianopsia due to a 17 × 17 × 20 mm nonfunctioning pituitary macroadenoma compressing the optic chiasm. Endocrine testing revealed corticotropic and thyrotropic insufficiencies, for which hydrocortisone and levothyroxine were initiated. Surgery was initially declined, but later reconsidered due to persistent symptoms. Preoperative imaging unexpectedly showed complete spontaneous resolution of the lesion, with normalization of visual function and no new endocrine deficits. The patient remained stable at 12-month follow-up. Conclusion: This case highlights complete spontaneous regression of a symptomatic macroadenoma without apoplexy, possibly influenced by postpartum hormonal factors. Although surgical decompression remains the standard treatment for lesions causing chiasmal compression, this exceptional case demonstrates that, in rare situations where surgery is declined, repeat imaging and close monitoring may reveal unexpected regression. Careful multidisciplinary evaluation is essential to balance the risks of waiting against the potential for spontaneous resolution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.