Evidence map›Paper›PMID 41409788›Full record

ReviewInternational journal of preventive medicine2025

The Prevalence of Polymorphism in Vitamin D Receptor Genes and its Correlation with Susceptibility to Pulmonary Tuberculosis in the Global Population (2010-2023): A Systematic Review and Meta-Analysis.

Alireza Firouzjahai, Mahdie Taheri, Siamak Sabaghi, Radmehr Nozari, Samaneh Rouhi, Mohammad Ranaee, Zahra Ahmadnia, Sara Babazadeh, Somayeh Ahmadi Goorji, Afra Hosseinpanahi

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PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of preventive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alireza FirouzjahaiClinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Mahdie TaheriClinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Siamak SabaghiClinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Radmehr NozariMedicine Department, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Samaneh RouhiClinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Mohammad RanaeeClinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Zahra AhmadniaClinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Sara BabazadehClinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Somayeh Ahmadi GoorjiDepartment of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Afra HosseinpanahiLung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene play a significant role in the susceptibility to pulmonary tuberculosis (TB). Recognition of these polymorphisms is a crucial aspect of TB treatment. This study aims to investigate the effects of VDR gene polymorphisms on TB susceptibility. Methods: This research encompassed studies from 2010 to 2023. The synthesis and integration of data, along with meta-analysis and qualitative heterogeneity investigation, were conducted using a documentation table. STATA 14 software was employed for meta-analysis, utilizing both the fixed and random effects models. To assess data heterogeneity, the Q test ( Results: The highest pooled OR of genotype polymorphism of the VDR gene was associated with the FF (OR: 1.165, 95% CI; 0.953- 1.424), TT (OR: 1.163, 95% CI; 1.018- 1.329), Tt (95% CI: 0.768-1.095) and tt (95% CI: 0.594-1.416) each one OR: 0.917, Ff (OR: 0.888, 95% CI; 0.699- 1.130, weight: 100.00) and ff (OR: 0.648, 95% CI; 0.418- 1.006, weight: 100.00), respectively. The statistical difference between case and control groups was found to be significant in terms of TT genotype ( Conclusions: The FF and TT genotypes exhibited the highest prevalence of polymorphism.

Indexed as

Polymorphismpulmonary tuberculosisvitamin D receptor genes

Identifiers

PMID41409788
PMCPMC12707840

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.