ArticleFrontiers in aging neuroscience2025
Correlation between cerebral small vessel disease and postural instability/gait difficulty subtype in Parkinson's disease patients.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Triglyceride-glucose index is associated with cerebral small vessel disease-related motor impairment in Parkinson's disease: a mediation analysis.Frontiers in aging neuroscience · 2026Article
- Occupational dust exposure and cerebral small vessel disease: a public health perspective on prevention and early detection.Frontiers in medicine · 2026Review
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8 authors.
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Abstract
Background: Postural instability/gait difficulty (PIGD) subtype in Parkinson's disease (PD) portends poorer prognosis and limited treatment response. While cerebral small vessel disease (CSVD) is implicated in motor impairment, its specific association with PIGD remains underexplored. This study aims to investigate the correlation between the severity of CSVD and PIGD subtype in PD patients. Methods: This cross-sectional study enrolled 161 PD patients (mean age 71.14 ± 7.04 years). Motor subtyping [postural instability and gait difficulty (PIGD)/tremor-dominant (TD)/intermediate type (IT)] used MDS-UPDRS-derived ratios. CSVD burden was quantified via two validated MRI-based scores: the total CSVD burden score (range 0-4) and modified CSVD burden score (range 0-6). Multivariate logistic regression analysis, which adjusted for age, gender, disease duration, and vascular risk factors, was used to explore the correlation between CSVD burden and PIGD. Results: The prevalence of PIGD was 49.07% ( Conclusion: Global CSVD burden was independently associated with the occurrence of PIGD in PD. CSVD assessment may help identify PD patients at the highest risk for axial motor disability, highlighting the convergence of vascular and neurodegenerative pathologies.
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