Evidence map›Paper›PMID 41409743›Full record

ArticleFrontiers in cardiovascular medicine2025

Case Report: Simultaneous presentation of end-stage heart failure with cardiogenic shock requiring emergency transplantation in monozygotic twins with myofibrillar myopathy: a previously unknown genetic disease?

Giovanni Battista Luciani, Cristina Panico, Antonella Galeone, Vittoria Medeghini, Matteo Ciuffreda, Rossana Mineri, Livio San Biagio, Paola Tonin, Gaetano Nicola Vattemi, Stiljan Hoxha and 7 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Giovanni Battista Luciani *Division of Cardiac Surgery, Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, Verona, Italy.
Cristina Panico *Cardiovascular Department, IRCCS Humanitas Research Hospital, Milan, Italy.
Antonella GaleoneDivision of Cardiac Surgery, Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, Verona, Italy.
Vittoria MedeghiniCardiovascular Department, IRCCS Humanitas Research Hospital, Milan, Italy.
Matteo CiuffredaDivision of Cardiology, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Rossana MineriUnit of Medical Genetics, IRCCS Humanitas Research Hospital, Milan, Italy.
Livio San BiagioDivision of Cardiac Surgery, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Paola ToninDivision of Neurology, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Gaetano Nicola VattemiDivision of Neurology, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Stiljan HoxhaDivision of Cardiac Surgery, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Alessandra FrancicaDivision of Cardiac Surgery, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Gina MazzeoDivision of Cardiac Surgery, Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, Verona, Italy.
Alessia GambaroDivision of Cardiology, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Leonardo GottinDivision of Anesthesiology, Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, Verona, Italy.
Giuseppe FaggianDivision of Cardiac Surgery, Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, Verona, Italy.
Francesco OnoratiDivision of Cardiac Surgery, Department of Surgery, Dentistry, Pediatrics and Gynecology, University of Verona, Verona, Italy.
Elisa Di PasqualeCardiovascular Department, IRCCS Humanitas Research Hospital, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the rare case of 16-year-old male monozygotic twins, born to first cousins, who developed acute end-stage heart failure due to dilated cardiomyopathy, requiring emergency heart transplantations within days of each other. Both twins presented with rapid-onset symptoms and progressed to refractory cardiogenic shock despite inotropic support, necessitating veno-arterial extracorporeal membrane oxygenation. Heart transplantation was performed within 3 weeks of admission, and both twins have remained clinically stable 3 years posttransplantation. Family history was negative for cardiomyopathy. Genetic testing identified the following four shared variants: a homozygous

Indexed as

cardiomyopathygenetic testingheart failureheart transplantation (HT)myofibrillar myopathy

Identifiers

PMID41409743
PMCPMC12705532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.