Evidence map›Paper›PMID 41409708›Full record

ArticleNational science review2025

Inhibition of SERT and NMDAR synergistically confers rapid antidepressant effects of ketamine.

Huoqing Luo, Ming Chen, Yingjie Ning, Li Ren, Yiping Lu, Junyou Sun, Xiaona Zhu, Mingzi Ran, Juan Guo, Chen Lu and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Huoqing LuoDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Ming ChenMOE Frontier Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Yingjie NingSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Li RenSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Yiping LuChinese Institute for Brain Research, Beijing 102206, China.
Junyou SunChinese Institute for Brain Research, Beijing 102206, China.
Xiaona ZhuSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Mingzi RanDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Juan GuoDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Chen LuSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Chengyu FanSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Jianjun ChengiHuman Institute, ShanghaiTech University, Shanghai 201210, China.
Weimin ZhengSchool of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Yue HuDepartment of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Tangsheng LuNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China.
Gang WangBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Wenzhi SunChinese Institute for Brain Research, Beijing 102206, China.
Hailong DongDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Jingpeng GeSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Ji HuSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While

Indexed as

ketamineNMDARrapid antidepressant effectsSERTvasoactive intestinal peptide-expressing interneurons

Identifiers

PMID41409708
PMCPMC12707061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.