Evidence map›Paper›PMID 41409681›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Sex-Specific Genetic Architecture and Comorbidities of Alcohol Use Behaviors.

Laura Vilar-Ribó, Mariela V Jennings, Aisha Sallah, Zeal Jinwala, Hayley Ha Thorpe, Sevim B Bianchi, John Meredith, Kyra Feuer, Lydia Rader, Natasia Courchesne-Krak and 15 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Laura Vilar-RibóDepartment of Psychiatry, University of California San Diego, La Jolla CA, USA.ORCID 0000-0001-8758-523X
Mariela V JenningsDepartment of Psychiatry, University of California San Diego, La Jolla CA, USA.
Aisha SallahGenetics and Epigenetics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0009-1199-6900
Zeal JinwalaDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States.ORCID 0009-0005-5062-0827
Hayley Ha ThorpeDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID 0000-0002-7263-637X
Sevim B BianchiDepartment of Psychiatry, University of California San Diego, La Jolla CA, USA.ORCID 0009-0007-6000-2883
John MeredithDepartment of Psychiatry, University of California San Diego, La Jolla CA, USA.
Kyra FeuerDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States.ORCID 0000-0003-3704-6136
Lydia RaderInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO.ORCID 0000-0002-2290-7653
Natasia Courchesne-KrakDepartment of Psychiatry, University of California San Diego, La Jolla CA, USA.ORCID 0000-0002-9231-647X
Maria NiarchouDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-8855-7393
Jared BalbonaVirginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA.ORCID 0000-0003-4466-248X
23andMe Research Team
Sarah L Elson23andMe, Research Institute, Palo Alto, CA, USA.ORCID 0000-0002-3211-3750
Pierre Fontanillas23andMe, Research Institute, Palo Alto, CA, USA.ORCID 0000-0002-8944-4454
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO.ORCID 0000-0003-0394-777X
Lea K DavisDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-5143-2282
Alexander S HatoumWashington University School of Medicine, Department of Psychiatry, St. Louis MO.
Travis T MallardCenter for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-3265-3001
Daniel E GustavsonInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO.ORCID 0000-0002-1470-4928
Hang ZhouDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7694-6391
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla CA, USA.ORCID 0000-0003-3634-0747
Jeanne E SavageDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, The Netherlands.ORCID 0000-0002-2034-8341
Rachel L KemberDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States.ORCID 0000-0001-8820-2659
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla CA, USA.ORCID 0000-0001-6137-5699

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Interdisciplinary Research Fellowship in NeuroAIDSR25MH081482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIANA CHERNER · 2007 to 2026
$5.2M
2/7 PsycheMERGE: Advancing Precision PsychiatryR01MH137218 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI JORDAN W SMOLLER · 2024 to 2026
$2.4M
Building Bridges to Allow Cross-species Translational genetics for the Study of AddictionDP1DA054394 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANCHEZ ROIGE, SANDRA · 2021 to 2025
$2.4M
Graduate Training Program in BioinformaticsT32GM139790 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAFNA, VINEET, GAASTERLAND, THERESA · 2021 to 2025
$2.1M
1/7-PsycheMERGE: Advancing Precision PsychiatryR01MH137220 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Lea K Davis · 2024 to 2026
$1.8M
4/7-PsycheMERGE: Advancing Precision PsychiatryR01MH137212 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Rachel Lorraine Kember · 2024 to 2026
$1.5M
Identifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics dataK01DA051759 · NIDA · WASHINGTON UNIVERSITY · PI JOHNSON, EMMA COVEY · 2021 to 2025
$816k
NCATS NIH HHS UL1 TR001878NIDA NIH HHS DP1 DA054394NIDA NIH HHS K01 DA051759NIGMS NIH HHS T32 GM139790NIMH NIH HHS R01 MH137212NIMH NIH HHS R01 MH137218NIMH NIH HHS R01 MH137220NIMH NIH HHS R25 MH081482
6 · The paper itself

Abstract

Sex differences in alcohol use behaviors are well-established: males typically engage in heavier and more frequent drinking and exhibit more externalizing behaviors (e.g., other substance use), while females often transition to dependence more rapidly and present more internalizing psychopathology (e.g., depression). The biological mechanisms underpinning these differences are relatively unknown. In this study, we investigated the sex-differentiated genetic architecture of 11 alcohol use phenotypes pertaining to frequency, quantity and problematic use by leveraging sex-stratified genome-wide association studies (Ns 40,335 to 613,148). Specifically, we compared SNP-based heritability (

Identifiers

PMID41409681
PMCPMC12706599

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.