ArticleInfection and drug resistance2025
Impact of an Antimicrobial Stewardship Program on Pre-Therapy Pathogen Detection Specimen Submission, Antimicrobial Use, and Resistant Pathogens: An Interrupted Time Series Analysis.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Inappropriate antibiotic use drives antimicrobial resistance (AMR). Performing pathogen detection before initiating antimicrobial therapy is essential for antimicrobial stewardship (AMS), enabling targeted treatment. Robust evidence on multifaceted interventions' sustained impact on pre-therapy pathogen detection specimen submission rates, AMS metrics, and multidrug-resistant organisms (MDROs) is limited. Methods: Interrupted time series analysis evaluated a comprehensive AMS intervention (April 2023) at a tertiary care hospital in China (April 2022-May 2025). Interventions included: team establishment, lab expansion, education, electronic restrictions for restricted/special use-levels antibiotics (mandating pre-therapy pathogen detection specimen submission rate), audit/feedback, and monitoring. Segmented regression assessed level (immediate) and slope (trend) changes in pre-therapy pathogen detection specimen submission rate, antimicrobial use, costs, and MDRO isolate rates. Results: Post-intervention, overall pre-therapy pathogen detection specimen submission rate increased immediately (+9.82%, P=0.009) with sustained monthly growth (+1.21%, P<0.001); increases occurred across all antimicrobial classes (all P<0.05). Antimicrobial use intensity reversed significantly from a pre-intervention upward trend (β Conclusion: The intervention significantly improved pre-therapy pathogen detection specimen submission rate and optimized antimicrobial use (reduced intensity/costs), but demonstrated limited resistance impact beyond CRKP reduction. Sustainable AMR control requires integrating diagnostic stewardship with infection prevention programs.
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