ArticleInfection and drug resistance2025
Construction of a Risk Factor Model for Wound Infection After Ileostomy for Rectal Cancer and Its Relationship with Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 (NLRP3) Gene Polymorphism.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To establish a predictive model for wound infection after ileostomy for rectal cancer and its relationship with nucleotide-binding oligomerisation domain-like receptor thermal protein domain-associated protein 3 Methods: A total of 347 samples were randomly divided into two groups: the model group (n = 260) and the verification group (n = 87). The patients in the model group were further divided into the infection group (n = 96) and the non-infection group (n = 164). Multivariate logistic regression was used to analyse the influencing factors of postoperative infection. The TaqMan probe method was used for genotyping. Results: The results of multivariate logistic regression analysis showed that age >65 years, diabetes, operation time >105 minutes, loop colostomy and abnormal transepidermal water loss (TEWL) were independent risk factors. The risk value of postoperative wound infection predicted by the nomogram model reached 0.93, corresponding to a maximum predicted infection probability of 92.68%. The area under the receiver operating characteristic curve for the nomogram model was 0.869 ( Conclusion: This study identified the independent risk factors for postoperative wound infection. Patients with the G allele have a higher risk of postoperative infection, and
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