Evidence map›Paper›PMID 41409579›Full record

ArticleRSC chemical biology2026

Differential regulation of SIRT5 activity by reduced nicotinic acid riboside (NARH).

Abu Hamza, Dickson Donu, Emily Boyle, Rasajna Madhusudhana, Alyson Curry, Yana Cen

Abstract read
In one paragraph

Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Abu HamzaDepartment of Medicinal Chemistry, Virginia Commonwealth University Richmond VA 23219 USA ceny2@vcu.edu +1 804-828-7405.
Dickson DonuDepartment of Medicinal Chemistry, Virginia Commonwealth University Richmond VA 23219 USA ceny2@vcu.edu +1 804-828-7405.
Emily BoyleDepartment of Medicinal Chemistry, Virginia Commonwealth University Richmond VA 23219 USA ceny2@vcu.edu +1 804-828-7405.
Rasajna MadhusudhanaDepartment of Medicinal Chemistry, Virginia Commonwealth University Richmond VA 23219 USA ceny2@vcu.edu +1 804-828-7405.
Alyson CurryDepartment of Medicinal Chemistry, Virginia Commonwealth University Richmond VA 23219 USA ceny2@vcu.edu +1 804-828-7405.
Yana CenDepartment of Medicinal Chemistry, Virginia Commonwealth University Richmond VA 23219 USA ceny2@vcu.edu +1 804-828-7405.ORCID https://orcid.org/0000-0001-6436-5744

Funding

Vermont INBRE Administrative Supplement 2024 AWD 118P20GM103449 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Julie Dragon · 2012 to 2026
$58.4M
Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Small molecule approach to activate human SIRT5R01GM143176 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI CEN, YANA · 2022 to 2025
$1.7M
NCATS NIH HHS UL1 TR002649NIGMS NIH HHS P20 GM103449NIGMS NIH HHS R01 GM143176
6 · The paper itself

Abstract

SIRT5, one of the human sirtuins, catalyzes the removal of acyl substitutions from lysine residues in a NAD

Identifiers

PMID41409579
PMCPMC12707241

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.