ArticleClinical Medicine Insights. Oncology2025
Predictive Value of Patient-Derived Tumor Cell Cluster-Based Drug Sensitivity Assay in Advanced NSCLC.
Article in Clinical Medicine Insights. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Patient-derived tumor cell cluster (PTC)-based drug sensitivity assays show promise for enabling precision drug selection; however, their predictive value in advanced non-small cell lung cancer (NSCLC) requires further elucidation. Methods: To assess the concordance between PTC-based drug sensitivity and clinical outcomes, we conducted a single-center prospective cohort study at Peking University Third Hospital from August 2021 to August 2024. We enrolled 38 consecutive patients, from whom 44 fresh tumor specimens were obtained for PTC-based drug sensitivity assays and compared with paired clinical outcomes of chemotherapy and targeted therapy regimens. Concordance was assessed using the Kappa statistic and receiver operating characteristic curve analysis. A Cox proportional-hazard model was used to identify prognostic factors for progression-free survival (PFS). Results: We observed an 81.8% (36/44) concordance between the PTC killing rate (>0% vs 0%) and the best overall clinical response (disease controlled vs disease progression per RECIST v1.1) (Kappa = 0.484, area under the curve (AUC) = 0.740). The concordance with the local response of the biopsied lesions was even higher, at 87.5% (35/40) (Kappa = 0.593, AUC = 0.841). A PTC killing rate >0% was correlated with significantly longer PFS (8.6 vs 2.0 months, Conclusions: These findings validate the predictive value of the PTC-based drug sensitivity assay in guiding personalized treatment for patients with advanced NSCLC and support its clinical translation. Registration: Chinese Clinical Trial Registry, Registration No.: ChiCTR2100048791, https://www.chictr.org.cn/showproj.html?proj=129885.
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