ArticleAging and cancer2025
Age-Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice.
Article in Aging and cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
Abstract
Background: Advancing age increases cancer risk due to DNA damage accumulation and a decline in immune function. While aging is known to reduce adaptive immunity, it also leads to an increase in immunosuppressive myeloid cells, which promote tumor progression and are linked to poorer outcomes in melanoma. Aims: This study aims to characterize how aging alters Gr-1 Methods: Subcutaneous tumor growth using several YUMM melanoma cell lines was evaluated in 2-, 6-, and 12-month-old wild-type mice. Immune profiling of tumor-bearing and age-matched healthy mice was performed via flow cytometry and single-cell RNA sequencing. Gr-1 Results: Aging only accelerated YUMM1.7 tumor growth and was associated with increased myeloid-derived suppressor cells, regulatory T cells, and exhausted T cells. Gr-1 Conclusion: Our findings highlight a context-dependent immune response to melanoma with aging, indicating that age-related variations in melanoma growth and immunotherapy response are not ubiquitous. Age-accelerated tumor growth is associated with increased immunosuppressive cell populations alongside enhanced Gr-1
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