Evidence map›Paper›PMID 41409299›Full record

SynthesisFrontiers in immunology2025

High prevalence of baseline Non-R5 viral tropism in PLWH is associated with immune damage: a systematic review and meta-analysis.

Yangyang Liu, Defu Yuan, Yueqi Yin, Qian He, Meng Zhao, Hongfei Ma, Pingmin Wei, You Ge

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Yangyang LiuDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Defu YuanDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Yueqi YinYinzhou District Center for Disease Control and Prevention, Ningbo, China.
Qian HeSchool of Public Health, Xinjiang Medical University, Urumqi, China.
Meng ZhaoDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Hongfei MaDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Pingmin WeiDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
You GeDepartment of Infectious Disease, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This systematic review and meta-analysis aims to characterize the distribution of HIV-1 viral tropism at diagnosis among people living with HIV (PLWH) and examine its association with baseline CD4 Method: Observational studies reporting viral tropism prevalence and/or baseline CD4 Results: 27 articles (N = 9372) were included in this study to analyze the distribution of viral tropism, and the prevalence of Non-R5 tropism was 15.68%. Subgroup analysis showed that the prevalence of Non-R5 IDU (27.86%) was significantly higher than that of sexual transmission (15.29%) and other routes (4.62%). The prevalence of Non-R5 tropism in the CRF01_AE subtype group (30.02%) was significantly higher than that of the B subtype (15.33%) and other subtypes (3.44%) ( Conclusion: Our study find that PLWH with Non-R5 virus had more severe immune damage at diagnosis compared to PLWH with R5 virus. This can update the baseline status of patients in clinical practice. since this is a cross-sectional study, future cohort studies should be conducted to verify the relationship between tropism and changes in immunological indicators. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251088996.

Indexed as

HIV-1HIV InfectionsViral TropismCD4 Lymphocyte CountCD4-Positive T-LymphocytesHumansPrevalenceCD4+T cellepidemiologyHIV-1immuneviral tropism

Identifiers

PMID41409299
PMCPMC12705401

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.