ArticleFrontiers in immunology2025
Association of HLA-DQA1*06:01 and DPB1*05:01:01G alleles with susceptibility to end-stage liver disease with HBV infection in liver transplant recipients from the Zhejiang Han population, China.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: It has been reported that HLA was associated with susceptibility to various liver diseases. However, data on HLA in end-stage liver disease (ESLD) patients are limited. Therefore, this study aimed to explore the association of HLA with susceptibility to ESLD in patients undergoing liver transplantation (LT). Methods: 108 ESLD patients who underwent LT from July 1, 2023, to December 31, 2024, were investigated. At the same time, 453 blood donors were randomly selected as healthy controls. Their specimens were genotyped for 11 HLA loci using next-generation sequencing (NGS). Results: There was no significant difference in gender and ABO blood group between the two groups ( Conclusion: Our study suggested that HLA-DQA1*06:01 and HLA-DPB1*05:01:01G alleles may be associated with susceptibility to ESLD in liver transplant recipients, particularly in cases related to HBV infection.
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