Evidence map›Paper›PMID 41409241›Full record

ArticleFrontiers in oncology2025

Association between intraoperative dexmedetomidine and survival outcomes after colorectal cancer surgery: a retrospective cohort study.

Shirong Chen, Lu Gan, Ruosi Zhang, Xiang Huang, Pei Li, Jiawei Ni, Kexuan Liu, Huamin Liu, Cai Li

Abstract read
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In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shirong Chen *Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Lu Gan *Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ruosi ZhangDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiang HuangDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Pei LiDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jiawei NiDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Kexuan LiuDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Huamin LiuDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Cai LiDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The impact of dexmedetomidine (DEX) on postoperative survival outcomes in cancer remains controversial. Our study aimed to investigate the influence of intraoperative DEX administration on postoperative mortality outcomes in colorectal cancer patients. Methods: This was a retrospective cohort study of adult patients undergoing colorectal cancer surgery in a large academic hospital in southern China between 2011 and 2018. Patients were divided into two groups: the DEX group, in which patients received intravenous DEX during the operation, and the non-DEX group. The primary endpoint was overall death or tumor recurrence, deriving two outcome variables: "all-cause death" and "recurrence or death." Secondary endpoints included total hospital stay, postoperative hospital stay, and postoperative complications. Multivariable Cox regression and propensity score matching were used to control confounders. Results: A total of 1,367 adult patients were included, of which 485 pairs were matched. Patients who received intraoperative DEX had a lower all-cause death rate (8.0% Conclusions: In patients undergoing colorectal cancer surgery, intraoperative DEX administration was associated with better postoperative survival.

Indexed as

all-cause deathcolorectal cancerdexmedetomidinepostoperative outcomestumor recurrence

Identifiers

PMID41409241
PMCPMC12705362

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.