ArticleBioinorganic chemistry and applications2025
Polydopamine-Functionalized Zinc Oxide Nanoparticles as a Root Canal Sealer: Characterization, Biological, and Physicochemical Properties.
Article in Bioinorganic chemistry and applications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Polydopamine-Functionalized Zinc Oxide Nanoparticles as a Root Canal Sealer: Characterization, Biological, and Physicochemical Properties.Bioinorganic chemistry and applications · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Polydopamine (PDA) exhibits superior adhesion and notable bioactive characteristics, such as antimicrobial activity and favorable biocompatibility with host tissues, while zinc oxide (ZnO) nanoparticles (NPs) have proved to provide antibacterial and remineralizing properties. Combining these benefits, PDA with ZnO NP (PDA@ZnO NP) could offer superior antimicrobial activity, adhesion, and biocompatibility, possibly making it a promising alternative to conventional sealers like AH Plus (Dentsply Sirona, Germany) and zinc oxide eugenol (ZOE) (Prevest DenPro Limited, India). Aim: An effort has been made in this study to assess and compare the physicochemical properties, sealing efficiency, antibacterial potential, and biocompatibility of PDA@ZnO NP-based root canal sealer with conventional AH Plus and ZOE sealers. Materials and Methods: The PDA@ZnO NP sealer was synthesized and characterized using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, and zeta potential analysis. Physicochemical properties, including setting time, flow, pH, radiopacity, sealing ability, and biological properties such as biocompatibility and antibacterial property against Results: The PDA@ZnO NP sealer exhibited superior dentinal tubule penetration, enhanced adhesion, and strong antibacterial properties compared with AH Plus and ZOE; statistical tests showed significant differences among groups for sealing ability and antibacterial activity ( Conclusion: The outcomes of this study highlighted that the PDA@ZnO NP sealer demonstrated superior sealing ability, enhanced dentinal tubule penetration, and favorable cytocompatibility, comparable to AH Plus and more favorable than ZOE at early timepoints. It also showed strong antibacterial efficacy and improved physicochemical properties. These findings suggest that PDA@ZnO NP sealer may serve as a promising alternative for clinical endodontic applications, potentially contributing to improved treatment outcomes and long-term success in root canal therapy.
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