Evidence map›Paper›PMID 41409157›Full record

ArticlebioRxiv : the preprint server for biology2025

Development of Long-Term Human Adipocyte Organoids Manifesting Aging in Response to Intermittent Hypoxia.

Yunzhou Dong, Jingjing Wang, Feifei Feng, Isra H Ali, Shahid Karim, Joshua Bock, Virend K Somers

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yunzhou DongDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902.
Jingjing WangDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902.
Feifei FengDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902.
Isra H AliDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902.
Shahid KarimDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902.
Joshua BockDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902.
Virend K SomersDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902.

Funding

CARDIOVASOLOGYT32HL007111 · NHLBI · MAYO CLINIC ROCHESTER · PI Barry A. Borlaug · 1985 to 2026
$8.7M
Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KAPOOR, EKTA · 2018 to 2022
$7.7M
Disease Mechanisms in Sleep ApneaR01HL065176 · NHLBI · MAYO CLINIC ROCHESTER · PI SOMERS, VIREND K · 1999 to 2021
$5.8M
Mayo Clinic Building Interdisciplinary Research Careers in Women’s HealthK12AR084222 · NIAMS · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2023 to 2024
$733k
NHLBI NIH HHS R01 HL065176NHLBI NIH HHS T32 HL007111NIAMS NIH HHS K12 AR084222NIA NIH HHS U54 AG044170
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) (and consequent intermittent hypoxia (IH)) is increasingly recognized as a driver of adipose tissue dysfunction, insulin resistance, and aging. However, current

Indexed as

cellular agingFat organoid aging modelHuman adipocyte organoidsintermittent hypoxiaOSA

Identifiers

PMID41409157
PMCPMC12707283

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.