ArticlebioRxiv : the preprint server for biology2025
Multimodal MRI Insights into Glymphatic Clearance and Blood-Brain Barrier Integrity in Healthy Aging.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Aerospace stressors and brain health in military aviators: a glymphatic-neurovascular framework.Frontiers in physiology · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is associated with impaired CSF clearance in preclinical models, but its impact on blood-brain barrier (BBB) health and glymphatic function in humans remains unclear. We aimed to compare healthy younger and older adults using multimodal MRI to assess age-related changes in BBB permeability and glymphatic clearance, and to examine the relationships between these measures. Thirty participants were recruited (12 younger, 26 ± 3 years; 18 older, 75 ± 7 years). Diffusion-prepared arterial spin labeling measured the water exchange rate (Kw) across the BBB; free water (FW) imaging quantified extracellular free water in white matter; and diffusion tensor imaging along perivascular spaces (DTI-ALPS) assessed glymphatic function. Older individuals showed reduced whole-brain Kw (p=0.021), increased white matter FW (p=0.002), and reduced DTI-ALPS (p<0.001) compared to younger adults. Kw associated with both DTI-ALPS (β=0.402×10
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Registered trials
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